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1994-10-25
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Document 3080
DOCN M94A3080
TI Immune activation markers and CD4 cells counts in HIV clinical stages.
Predictors of advanced disease?
DT 9412
AU Portilla J; Sanchez J; Boix V; Munoz C; Sen ML; Reus S; Perez-Mateo M;
Hospital General de Alicante, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):158 (abstract no. PB0058). Unique
Identifier : AIDSLINE ICA10/94369495
AB OBJECTIVE: To evaluate the relationship among serum neopterin, beta 2
microglobulin, IgG, IgA, IgM, clinical stage and CD4 lymphocyte counts.
METHODS: In 108 HIV patients (IVDU 80%), 89 men and 19 women, we
determined CD4 cells by flow cytometry; beta 2 microglobulin, IgG, IgA e
IgM by immunonefelometry and serum neopterin by RIA. The patients were
classificated according to the CDC staging system (1987): stage A (II,
III), stage B (IVA, IVC2), stage C (case definition for AIDS, CDC 1987).
Statistical analysis: analisis of variance, Student's t-test and
Pearson's correlation test. TABULAR DATA, SEE ABSTRACT VOLUME. There was
no correlation between the immune markers and the CD4 counts.
CONCLUSIONS: 1) IgA levels are increased in advanced HIV disease. 2) IgA
is the only immunoglobulin with prognostic value. 3) Elevations of IgA
and serum neopterin and run down of CD4 cell counts are independents
markers of AIDS. 4)Like others, this study shows that beta 2
microglobulin is not a good prognostic marker when HIV patients are
preferently IVDU.
DE beta 2-Microglobulin/METABOLISM Adult Biopterin/ANALOGS &
DERIVATIVES/BLOOD Human HIV
Infections/CLASSIFICATION/*DIAGNOSIS/IMMUNOLOGY Immunoglobulins/BLOOD
*Leukocyte Count Lymphocyte Transformation/*IMMUNOLOGY Prognosis
Substance Abuse, Intravenous/IMMUNOLOGY T4 Lymphocytes/*IMMUNOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).